Heterogeneity in protein expression induces metabolic variability in a modeledEscherichia colipopulation

Heterogeneity in protein expression induces metabolic variability in a modeled Escherichia coli population.

Stochastic gene expression can lead to phenotypic differences among cells even in isogenic populations growing under macroscopically identical conditions. Here, we apply flux balance analysis in investigating the effects of single-cell proteomics data on the metabolic behavior of an in silico Escherichia coli population. We use the latest metabolic reconstruction integrated with transcriptional...

Protein 53 expression in a mixed Labrador subcutaneous lymphoma

An 11 year – old mixed female Labrador was presented with two masses in trunk and neck. The tumoral masses were excised and sent for histopathological and immunohistochemical analyses. Histopathological examination of masses revealed diffuse infiltration of small sized lymphoid cells in subcutaneous tissue which were intense around the blood vessels. More than 10% lymphoid cells were CD3 positi...

Metabolic heterogeneity in cancer

Metabolic reprogramming has long been viewed as an important component of malignant transformation. Recent years have defined a large number of mechanisms by which oncogene-directed perturbations of signal transduction regulate intermediary metabolism, and conversely, by which metabolites themselves influence gene expression and other dimensions of systems biology. However, there is still littl...

Explaining Heterogeneity in Risk Preferences Using a Finite Mixture Model

This paper studies the effect of the space (distance) between lotteries' outcomes on risk-taking behavior and the shape of estimated utility and probability weighting functions. Previously investigated experimental data shows a significant space effect in the gain domain. As compared to low spaced lotteries, high spaced lotteries are associated with higher risk aversion for high probabilities o...

Advances and challenges in recombinant protein expression in Escherichia coli